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From the outside, D.O.M. looks at home among the historic aristocratic residences on leafy Via Giulia, in Rome's off-the-tourist-radar Regola neighborhood. But thanks to Italian architect Antonio Girardi, the interiors in the 17th-century building, which once housed a convent, are entirely of-the-moment (think sleek mirrored furniture, brass fixtures, and plush velvet rugs).